I finally got my hands on a Raspberry Pi 3 and wanted to see how it compares to the Pi 2 (review + benchmarks incoming!), but one of the first things I wanted to test was overclocking the microSD clock for better disk I/O. On average, with all the cards I've tested so far, overclocking the microSD reader resulted in 25-50% better performance for real-world disk operations (benchmarks further down in this post). And with a reliable power supply, you shouldn't need to worry about reliability or corruption (in my limited stress testing, I only had one corruption, and that was when I was using my cheaper iClever power supply).